GDNF, NGF and BDNF as therapeutic options for neurodegeneration
SJ Allen, JJ Watson, DK Shoemark, NU Barua… - Pharmacology & …, 2013 - Elsevier
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …
[HTML][HTML] From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF)
C Géral, A Angelova, S Lesieur - Pharmaceutics, 2013 - mdpi.com
Neurodegenerative diseases represent a major public health problem, but beneficial clinical
treatment with neurotrophic factors has not been established yet. The therapeutic use of …
treatment with neurotrophic factors has not been established yet. The therapeutic use of …
[HTML][HTML] Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures
MC Cardenas-Aguayo, SF Kazim, I Grundke-Iqbal… - PloS one, 2013 - journals.plos.org
The level of brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family,
is down regulated in Alzheimer's disease (AD), Parkinson's disease (PD), depression …
is down regulated in Alzheimer's disease (AD), Parkinson's disease (PD), depression …
Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity
CK Boughton, KG Murphy - British journal of pharmacology, 2013 - Wiley Online Library
Obesity is a major worldwide public health issue. The physiological systems that regulate
body weight are thus of great interest as targets for anti‐obesity agents. Peptidergic systems …
body weight are thus of great interest as targets for anti‐obesity agents. Peptidergic systems …
Brain-derived neurotrophic factor loop 4 dipeptide mimetic GSB-106 activates TrkB, Erk, and Akt and promotes neuronal survival in vitro
TA Gudasheva, IO Logvinov… - Doklady …, 2013 - search.proquest.com
Brain Derived Neurotrophic Factor Loop 4 Dipeptide Mimetic GSB 106 Activates TrkB, Erk, and
Akt and Promotes Neuronal Survival i Page 1 ISSN 1607 6729, Doklady Biochemistry and …
Akt and Promotes Neuronal Survival i Page 1 ISSN 1607 6729, Doklady Biochemistry and …
In vivo delivery of DN: REST improves transcriptional changes of REST-regulated genes in HD mice
P Conforti, A Mas Monteys, C Zuccato, NJ Buckley… - Gene therapy, 2013 - nature.com
Current therapeutic strategies for Huntington's disease (HD) are focused on symptom
management of disease progression. Transcriptional dysregulation is one of the major …
management of disease progression. Transcriptional dysregulation is one of the major …
[HTML][HTML] Activation of TrkB with TAM-163 results in opposite effects on body weight in rodents and non-human primates
M Perreault, G Feng, S Will, T Gareski, D Kubasiak… - PloS one, 2013 - journals.plos.org
Strong genetic data link the Tyrosine kinase receptor B (TrkB) and its major endogenous
ligand brain-derived neurotrophic factor (BDNF) to the regulation of energy homeostasis …
ligand brain-derived neurotrophic factor (BDNF) to the regulation of energy homeostasis …
Дипептидный миметик 4-й петли мозгового нейротрофического фактора ГСБ-106 активирует TrkB, Erk, Akt и способствует выживаемости нейронов in vitro
ТА Гудашева, ИО Логвинов, ТА Антипова… - Доклады академии …, 2013 - elibrary.ru
Как видно из табл. 1, в условиях глутаматной ток сичности ГСБ 106 в концентрациях 10–
7 и 10–8 М проявляет нейропротективную активность, по вы раженности не …
7 и 10–8 М проявляет нейропротективную активность, по вы раженности не …
Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions
WM Pardridge, RJ Boado - US Patent 8,497,246, 2013 - Google Patents
US8497246B2 - Methods for diagnosing and treating CNS disorders by trans-blood-brain
barrier delivery of protein compositions - Google Patents US8497246B2 - Methods for …
barrier delivery of protein compositions - Google Patents US8497246B2 - Methods for …
Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF
C Gouarné, M Giraudon‐Paoli… - British Journal of …, 2013 - Wiley Online Library
Background and Purpose Olesoxime is a small cholesterol–oxime promoting rat embryonic
motor neurons survival in the absence of trophic factors. Because olesoxime can substitute …
motor neurons survival in the absence of trophic factors. Because olesoxime can substitute …