The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

Autophagy is an evolutionarily conserved process that promotes the lysosomal degradation
of intracellular components including organelles and portions of the cytoplasm. Besides …

Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

The non-canonical NF-κB pathway forms a major arm of NF-κB signalling that mediates
important biological functions, including lymphoid organogenesis, B-lymphocyte function …

Hepatitis C virus (HCV) interacts extensively with host factors to not only establish productive
infection but also trigger unique pathological processes. Our recent genome-wide siRNA …

The NF-kB pathway, which is ubiquitous in nature and evolutionarily conserved in most cell
types, 1 controls the expression of genes involved in multiple physiologic processes …

More than 100 human genetic skin diseases, impacting over 20% of the population, are
characterized by disrupted epidermal differentiation. A significant proportion of the 90 genes …

Nuclear factor κB (NF-κB) controls a multitude of physiological processes such as cell
differentiation, cytokine expression, survival and proliferation. Since NF-κB governs …

NF-κB activation within the epithelium has been implicated in the pathogenesis of asthma,
yet the exact role of epithelial NF-κB in allergen-induced inflammation and airway …

BAFF is a soluble factor required for B cell maturation and survival. BAFF-R signals via the
noncanonical NF-κB pathway regulated by the TRAF3/NIK/IKK1 axis. We show that deletion …