Children's Oncology Group's 2013 blueprint for research: acute myeloid leukemia
For the 365 children diagnosed with acute myeloid leukemia in the US annually, 5‐year
survival for patients on COG trials with low, intermediate, and high risk disease is 83%, 62 …
survival for patients on COG trials with low, intermediate, and high risk disease is 83%, 62 …
Treatment of infant leukemias: challenge and promise
P Brown - Hematology 2013, the American Society of …, 2013 - ashpublications.org
Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical
presentation in a uniquely vulnerable host, its poor response to current therapies, and its …
presentation in a uniquely vulnerable host, its poor response to current therapies, and its …
Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia
We evaluated the outcome of 482 children with acute myeloid leukemia (AML) enrolled in
the Associazione Italiana di Ematologia e Oncologia Pediatrica AML 2002/01 trial …
the Associazione Italiana di Ematologia e Oncologia Pediatrica AML 2002/01 trial …
The distribution of MLL breakpoints correlates with outcome in infant acute leukaemia
M Emerenciano, C Meyer, MB Mansur… - British journal of …, 2013 - Wiley Online Library
Acute leukaemia in early childhood‐and mainly infant leukaemia (IL)–is characterized by
acquired genetic alterations, most commonly by the presence of distinct MLL …
acquired genetic alterations, most commonly by the presence of distinct MLL …
High EVI1 expression is associated with MLL rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's …
Ectopic viral integration site‐1 (EVI 1) is highly expressed in certain cytogenetic subsets of
adult acute myeloid leukaemia (AML), and has been associated with inferior survival. We …
adult acute myeloid leukaemia (AML), and has been associated with inferior survival. We …
Prognostic features in acute megakaryoblastic leukemia in children without Down syndrome: a report from the AML02 multicenter trial and the Children's Oncology …
2 Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that
originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730–737. 3 van Rhenen A …
originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730–737. 3 van Rhenen A …
NUP98‐NSD1 fusion in association with FLT3‐ITD mutation identifies a prognostically relevant subgroup of pediatric acute myeloid leukemia patients suitable for …
S Akiki, SA Dyer, D Grimwade, A Ivey… - Genes …, 2013 - Wiley Online Library
The cytogenetically cryptic t (5; 11)(q35; p15) leading to the NUP98‐NSD1 fusion is a rare
but recurrent gene rearrangement recently reported to identify a group of young AML …
but recurrent gene rearrangement recently reported to identify a group of young AML …
Cytogenetic abnormalities and monosomal karyotypes in children and adolescents with acute myeloid leukemia: correlations with clinical characteristics and outcome
KN Manola, F Panitsas, S Polychronopoulou, A Daraki… - Cancer genetics, 2013 - Elsevier
The whole spectrum of chromosomal abnormalities and their prognostic significance in
children and adolescents with acute myeloid leukemia (AML) has not been fully elucidated …
children and adolescents with acute myeloid leukemia (AML) has not been fully elucidated …
Should evaluation for minimal residual disease be routine in acute myeloid leukemia?
E Coustan-Smith, D Campana - Current opinion in hematology, 2013 - journals.lww.com
MRD monitoring can help predicting the risk of relapse better than morphology and also
provide endpoints for clinical testing of experimental agents. MRD can be applied to guide …
provide endpoints for clinical testing of experimental agents. MRD can be applied to guide …
Outcome of pediatric patients with acute myeloid leukemia (AML) and− 5/5q− abnormalities from five pediatric AML treatment protocols: a report from the Children's …
DL Johnston, TA Alonzo, RB Gerbing… - Pediatric blood & …, 2013 - Wiley Online Library
Background Abnormalities of chromosome 5q (− 5/5q−) are associated with poor prognosis
in adults with acute myeloid leukemia (AML). However, there are no large studies on …
in adults with acute myeloid leukemia (AML). However, there are no large studies on …