Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …

Inflammation is a fundamental innate immune response to perturbed tissue homeostasis.
Chronic inflammatory processes affect all stages of tumour development as well as therapy …

Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

Mononuclear phagocyte plasticity includes the expression of functions related to the
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …

The number of cancer cases caused by being obese is estimated to be 20% with the
increased risk of malignancies being influenced by diet, weight change, and body fat …

Active, but dysfunctional, immune responses in patients with cancer have been studied in
several tumour types, but owing to the heterogeneity of cancer theories of common reaction …

There is widespread interest in macrophages as a therapeutic target in cancer. Here, we
demonstrate that trabectedin, a recently approved chemotherapeutic agent, induces rapid …

Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …

The tumor microenvironment is a complex framework, in which myeloid cells play important
roles in sculpting cancer development from tumor initiation to metastasis. Immune cells are …

Differentiation to different types of macrophages determines their distinct functions. Tumor-
associated macrophages (TAMs) promote tumorigenesis owing to their proangiogenic and …