Abstract Approximately 90% of the 2,000 children, adolescents, and young adults enrolled
each year in Children's Oncology Group acute lymphoblastic leukemia (ALL) trials will be …

Intensive multi‐agent chemotherapy regimens and the introduction of risk‐stratified therapy
have substantially improved cure rates for children with acute lymphoblastic leukaemia …

The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …

Purpose Five-year overall survival (OS) for children with B-cell precursor acute
lymphoblastic leukemia (B-ALL) exceeds 90% with risk-adapted therapy. Age, initial WBC …

Second Malignant Neoplasms After Treatment of Childhood Acute Lymphoblastic Leukemia -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Hypodiploidy (o46 chromosomes) is found in B5–8% of acute lymphoblastic leukemia (ALL).
1, 2 It may be subdivided into high hypodiploidy (40–45 chromosomes), low hypodiploidy …

Although acute lymphocytic leukemia (ALL) is the most common childhood cancer, genetic
predisposition to ALL remains poorly understood. Whole‐exome sequencing was performed …

Most children, adolescents and young adults with acute lymphoblastic leukaemia (ALL) in
first complete remission (CR 1) have an excellent prognosis with multi‐agent chemotherapy …

Extraordinary advances in the treatment outcome of childhood acute lymphoblastic leukemia
(ALL) rank as one of the most successful stories in the history of oncology, with the current …

In this article, experts will discuss some of the current challenges and future directions in the
treatment of pediatric ALL. The authors will offer expert guidance to practicing oncologists on …