[HTML][HTML] Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies
MA McArdle, OM Finucane, RM Connaughton… - Frontiers in …, 2013 - frontiersin.org
Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
F Demontis, R Piccirillo, AL Goldberg… - Disease models & …, 2013 - journals.biologists.com
A characteristic feature of aged humans and other mammals is the debilitating, progressive
loss of skeletal muscle function and mass that is known as sarcopenia. Age-related muscle …
loss of skeletal muscle function and mass that is known as sarcopenia. Age-related muscle …
Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association
The term “fat” may refer to lipids as well as the cells and tissue that store lipid (ie, adipocytes
and adipose tissue).“Lipid” is derived from “lipos,” which refers to animal fat or vegetable oil …
and adipose tissue).“Lipid” is derived from “lipos,” which refers to animal fat or vegetable oil …
[PDF][PDF] DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats
H Pintana, N Apaijai, N Chattipakorn… - J Endocrinol, 2013 - researchgate.net
Recent evidence has demonstrated that insulin resistance is related to the development of
type 2 diabetes mellitus. Our previous study found that high-fat diet (HFD) consumption …
type 2 diabetes mellitus. Our previous study found that high-fat diet (HFD) consumption …
Mechanisms in endocrinology: pathogenesis of type 2 diabetes in South Asians
LEH Bakker, MA Sleddering… - European journal of …, 2013 - academic.oup.com
The risk of developing type 2 diabetes mellitus (T2DM) is exceptionally high among both
native and migrant South Asians. T2DM occurs more often and at a younger age and lower …
native and migrant South Asians. T2DM occurs more often and at a younger age and lower …
[HTML][HTML] Doxorubicin treatment inhibits PPARγ and may induce lipotoxicity by mimicking a type 2 diabetes-like condition in rodent models
Doxorubicin-treated animals show elevated serum triglyceride and blood glucose levels.
Adipocytes play an important role in buffering blood glucose and lipids. A raise in serum …
Adipocytes play an important role in buffering blood glucose and lipids. A raise in serum …
[HTML][HTML] Effect of Mangiferin and Mahanimbine on Glucose Utilization in 3T3-L1 cells
BD Kumar, K Krishnakumar… - Pharmacognosy …, 2013 - ncbi.nlm.nih.gov
Background: Stem barks of Mangifera indica contain a rich content of mangiferin (xanthone
glucoside), whereas Murraya koenigii leaves contain rich sources of mahanimbine …
glucoside), whereas Murraya koenigii leaves contain rich sources of mahanimbine …
Exercise training‐induced adaptations associated with increases in skeletal muscle glycogen content
Chronic exercise training results in numerous skeletal muscle adaptations, including
increases in insulin sensitivity and glycogen content. To understand the mechanism leading …
increases in insulin sensitivity and glycogen content. To understand the mechanism leading …
Inhibitors of Fatty Acid Synthesis Induce PPARα‐Regulated Fatty Acid β‐Oxidative Genes: Synergistic Roles of L‐FABP and Glucose
H Huang, AL McIntosh, GG Martin, AD Petrescu… - PPAR …, 2013 - Wiley Online Library
While TOFA (acetyl CoA carboxylase inhibitor) and C75 (fatty acid synthase inhibitor)
prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not …
prevent lipid accumulation by inhibiting fatty acid synthesis, the mechanism of action is not …
Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans
BS Maciejewski, JL LaPerle, D Chen… - American Journal …, 2013 - journals.physiology.org
Alterations in fat metabolism, in particular elevated plasma concentrations of free fatty acids
and triglycerides (TG), have been implicated in the pathogenesis of Type 2 diabetes …
and triglycerides (TG), have been implicated in the pathogenesis of Type 2 diabetes …