OBJECTIVE: When primary chondrocytes are cultured in monolayer, they undergo
dedifferentiation during which they lose their phenotype and their capacity to form cartilage …

Mechanical cues exert considerable influence on the fates of stem cells and terminally
differentiated chondrocytes. The elucidation of the interactions between cell fate and …

Objective To determine if serum amyloid A (A-SAA) could be detected in human
osteoarthritic (OA) joints and further clarify if high A-SAA level in joints result from a local …

Withaferin A (WFA) is a major chemical constituent of Withania somnifera, also known as
Indian ginseng. Many recent reports have provided evidence of its anti-tumor, anti …

Thymoquinone (TQ), a bioactive ingredient of the volatile oil of black seed (Nigella sativa),
has been shown to possess anti-neoplastic and anti-inflammatory effects on a variety of …

The protein kinase C (PKC) signaling, a major regulator of chondrocytic differentiation, has
been also implicated in pathological extracellular matrix remodeling, and here we …

Abstract Resveratrol (trans-3, 4'-trihydroxystillbene), a naturally occurring polyphenolic
antioxidant found in grapes and red wine, elicits diverse biochemical responses and …

Articular cartilage is an avascular tissue with poor regenerative capacity following injury, a
contributing factor to joint degenerative disease. Cell‐based therapies for cartilage tissue …

Background Studies have shown the roles of miR-9 and its validated target, protogenin
(PRTG) in the differentiation of chondroblasts to chondrocyte and in the pathogenesis of …

Cartilage defects can be addressed with replacement strategies such as autologous
chondrocyte implantation (ACI). Expansion of autologous chondrocytes in vitro is an …