BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Glutathione (GSH) is a linchpin of cellular defences in plants and animals with
physiologically-important roles in the protection of cells from biotic and abiotic stresses …

Selenium is an essential micronutrient in mammals, but is also recognized as toxic in
excess. It is a non-metal with properties that are intermediate between the chalcogen …

Selenoproteins are essential molecules for the mammalian antioxidant network. We
previously demonstrated that targeted loss of all selenoproteins in mouse epidermis …

Oxidative stress in the male germ line is known to be a key factor in both the etiology of male
infertility and the high levels of DNA damage encountered in human spermatozoa. Because …

Selenium (Se) is an essential element involved in normal gonadal development,
gametogenesis, and fertilization. Molecular studies show that the gonads actively take up …

Oxidative stress, overproduction of reactive oxygen species (ROS) in relation to defence
mechanisms, is considered to be a major cause of male infertility. For protection against the …

Diabetes mellitus is one of the major metabolic disorders. Diabetes is recognized for severe
complications including diabetic nephropathy, neuropathy and retinopathy. Long-lasting …

Oxidative stress is a major common hallmark of many neurodegenerative disease such as
Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) …