Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

Review on the ability of different TLR agonists to orchestrate antitumor immune responses,
or promote tumor growth, underscoring the impact of choosing among TLR agonists when …

Tissue-resident memory T cells (TRM cells) provide superior protection against infection in
extralymphoid tissues. Here we found that CD103+ CD8+ TRM cells developed in the skin …

Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their
distribution and function in tissues remains largely unknown. Here, we present a unique …

Cytolytic activity by CD8+ cytotoxic T lymphocytes (CTLs) is a powerful strategy for the
elimination of intracellular pathogens and tumor cells. The destructive capacity of CTLs is …

Long-living memory stem T cells (TSCM) with the ability to self-renew and the plasticity to
differentiate into potent effectors could be valuable weapons in adoptive T-cell therapy …

After infection, many factors coordinate the population expansion and differentiation of CD8+
effector and memory T cells. Using data of unparalleled breadth from the Immunological …

The inhibitory receptor programmed cell death 1 (PD-1) plays a major role in functional
exhaustion of T cells during chronic infections and cancer, and recent clinical data suggest …

The decline of the immune system appears to be an intractable consequence of aging,
leading to increased susceptibility to infections, reduced effectiveness of vaccination and …

The CD8+ memory T cell population is heterogeneous, and it is unclear which subset (s)
optimally mediate the central goal of the immune system—protection against infection. Here …