Phosphatidylinositol 3‐phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling
KO Schink, C Raiborg, H Stenmark - BioEssays, 2013 - Wiley Online Library
Phosphatidylinositol 3‐phosphate (PtdIns3P) is generated on the cytosolic leaflet of cellular
membranes, primarily by phosphorylation of phosphatidylinositol by class II and class III …
membranes, primarily by phosphorylation of phosphatidylinositol by class II and class III …
Phosphoinositide 3‐kinases as accelerators and brakes of autophagy
Degradation of cytoplasmic material by autophagy plays a key role in protein homeostasis
and metabolic control, as well as in the removal of intracellular protein aggregates …
and metabolic control, as well as in the removal of intracellular protein aggregates …
[HTML][HTML] Roles of PI3K/AKT/PTEN pathway as a target for pharmaceutical therapy
S Matsuda, A Nakanishi, Y Wada… - The open medicinal …, 2013 - ncbi.nlm.nih.gov
Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids.
Because of their important role in signal transduction, the dysregulated metabolism of …
Because of their important role in signal transduction, the dysregulated metabolism of …
Rationale for targeting the PI3K/Akt/mTOR pathway in myeloproliferative neoplasms
N Bartalucci, P Guglielmelli, AM Vannucchi - Clinical Lymphoma Myeloma …, 2013 - Elsevier
The chronic myeloproliferative neoplasms (MPNs), are characterized by a Janus Kinase
(JAK)-2 V617F point mutation but this molecular abnormality does not explain by itself the …
(JAK)-2 V617F point mutation but this molecular abnormality does not explain by itself the …
From immunosuppression to immunomodulation: current principles and future strategies
J Kovarik - Pathobiology, 2013 - karger.com
Over the last few decades, tremendous progress has been made in understanding the
mechanisms of immune responses. This progress has also led to a more detailed …
mechanisms of immune responses. This progress has also led to a more detailed …
Proliferation of PTEN-deficient haematopoietic tumour cells is not affected by isoform-selective inhibition of p110β PI3-kinase and requires blockade of all class 1 PI3K …
C Stengel, E Jenner, K Meja… - British journal of …, 2013 - search.ebscohost.com
The article offers information on a study which examines proliferation of PTEN inhibitory
compounds which is negative regulator of Class 1 phosphatidylinositide 3-kinases (PI3Ks) …
compounds which is negative regulator of Class 1 phosphatidylinositide 3-kinases (PI3Ks) …
What can rheumatologists learn from translational cancer therapy?
It is well established that an intimate connection exists between inflammation and neoplasia.
Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site …
Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site …
Sensitivierung von Melanomzellen für die TRAIL-induzierte Apoptose mittels Signalwegsinhibitoren
SA Quast - 2013 - refubium.fu-berlin.de
Das Auftreten des malignen Melanoms, der aggressivsten Form des Hautkrebses, ist in den
letzten Jahrzehnten weltweit dramatisch angewachsen und wächst immer noch schneller …
letzten Jahrzehnten weltweit dramatisch angewachsen und wächst immer noch schneller …
Copanlisib
J Gras - Drugs of the Future, 2013 - access.portico.org
Dysregulation of the PI3K/mTOR/Akt signaling pathway is associated with numerous
cancers. Thereby, many components of this pathway have become attractive targets for …
cancers. Thereby, many components of this pathway have become attractive targets for …