A plethora of groundbreaking studies have demonstrated the importance of chromatin-
associated proteins and post-translational modifications of histones, proteins and DNA (so …

Transcription factors are an important target for cancer therapy, both through direct
anticancer effects and immunomodulatory actions. Newly developed delivery systems that …

Bromodomains have emerged as attractive candidates for the development of inhibitors
targeting gene transcription. Inhibitors of the bromo and extraterminal (BET) family recently …

Heart failure (HF) is driven by the interplay between regulatory transcription factors and
dynamic alterations in chromatin structure. Pathologic gene transactivation in HF is …

Bromodomains (BRDs) are epigenetic readers that recognize acetylated-lysine (KAc) on
proteins and are implicated in a number of diseases. We describe a virtual screening …

S6 kinase 2 (S6K2) is a member of the AGC kinases super-family. Its closest homolog,
S6K1, has been extensively studied along the years. However, due to the belief in the …

A capital conference: Influencing epigenetic mechanisms may be highly relevant for future
therapies of various diseases such as cancer, inflammation, and metabolic disorders …