The neurobiological correlates of childhood adversity and implications for treatment

AR Tyrka, DE Burgers, NS Philip… - Acta Psychiatrica …, 2013 - Wiley Online Library
Objective This article provides an overview of research on the neurobiological correlates of
childhood adversity and a selective review of treatment implications. Method Findings from a …

Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress–diathesis model of depression

L Booij, D Wang, ML Lévesque… - … Transactions of the …, 2013 - royalsocietypublishing.org
The functioning of the hypothalamic–pituitary–adrenal (HPA) axis and serotonergic (5-HT)
system are known to be intertwined with mood. Alterations in these systems are often …

Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence

MJ Essex, W Thomas Boyce, C Hertzman… - Child …, 2013 - Wiley Online Library
Fifteen‐year‐old adolescents (N= 109) in a longitudinal study of child development were
recruited to examine differences in DNA methylation in relation to parent reports of adversity …

Child abuse and epigenetic mechanisms of disease risk

BZ Yang, H Zhang, W Ge, N Weder… - American journal of …, 2013 - Elsevier
BACKGROUND: Child abuse is highly prevalent and associated with increased risk for a
range of health problems, including cancer, cardiovascular disease, diabetes, psychiatric …

Does intranasal oxytocin promote prosocial behavior to an excluded fellow player? A randomized-controlled trial with Cyberball

MME Riem, MJ Bakermans-Kranenburg… - …, 2013 - Elsevier
The neuropeptide oxytocin has been shown to stimulate prosocial behavior. However,
recent studies indicate that adverse early caregiving experiences may moderate the positive …

[HTML][HTML] Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal

MME Riem, MH van IJzendoorn, M Tops… - European …, 2013 - Elsevier
The neuropeptide oxytocin has been implicated in a variety of social processes. However,
recent studies indicate that oxytocin does not enhance prosocial behavior in all people in all …

Attachment, affective temperament, and personality disorders: A study of their relationships in psychiatric outpatients

K MacDonald, R Berlow, ML Thomas - Journal of affective disorders, 2013 - Elsevier
Background As the result of extensive translational and cross-disciplinary research,
attachment theory is now a construct with significant neuropsychiatric traction. The …

Gene× environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms …

JV Lavigne, LBK Herzing, EH Cook… - Development and …, 2013 - cambridge.org
Genetic factors can play a key role in the multiple level of analyses approach to
understanding the development of child psychopathology. The present study examined …

Epigenetic basis for the development of depression in children

BM Lester, E Conradt, CJ Marsit - Clinical obstetrics and …, 2013 - journals.lww.com
The growing field of epigenetics and human behavior affords an unprecedented opportunity
to discover molecular underpinnings of mental health disorders and pave the way for the …

Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of existing evidence

M Uddin, L Sipahi, J Li, KC Koenen - Depression and anxiety, 2013 - Wiley Online Library
There are well‐established sex differences in the prevalence of certain mental disorders.
Work in animal models has provided us with an emerging understanding of the role that …