Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous
system. The microglial production of immune factors is believed to play an important role in …

Microglia are regarded as macrophages in the central nervous system (CNS) and play an
important role in neuroinflammation in the CNS. Microglial activation has been strongly …

New findings• What is the topic of this review? This paper presents a review of the literature
of glutamate receptors and transporters in neuropathic pain and the role of glia in these …

Nearly every surgery can elicit a rather therapy-resistant chronic postoperative pain.
Preventive medicine is therefore anticipated with hopeful eyes, but requires a better …

One long standing aspect of microglia biology was never questioned; their involvement in
brain disease. Based on morphological changes (retracted processes and amoeboid shape) …

Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer
chemotherapy. However, the neural mechanisms underlying CNP remain enigmatic …

Amorphous mesoporous silica nanoparticles ('protocells') that support surface lipid bilayers
recently characterized in vitro as carrier constructs for small drug and DNA delivery are …

Abstract Background Spinal Toll-like receptors (TLRs) and signaling intermediaries have
been implicated in persistent pain states. We examined the roles of two major TLR signaling …