Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …

Epigenetics acts as an interface between environmental/exogenous factors, cellular
responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of …

Background Colonoscopy and sigmoidoscopy provide protection against colorectal cancer,
but the magnitude and duration of protection, particularly against cancer of the proximal …

Background A simple endoscopic classification to accurately predict deep submucosal
invasive (SM-d) carcinoma would be clinically useful. Objective To develop and assess the …

BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through
its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter …

We show that BRAF V600E initiates an alternative pathway to colorectal cancer (CRC),
which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway …

BACKGROUND: Sessile serrated adenomas/polyps (SSAs/Ps) are premalignant lesions
susceptible to being easily overlooked by endoscopists. A detailed description of the …

Background Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality. A
well-defined precursor lesion (adenoma) and a long preclinical course make CRC a …

Background: Most colorectal cancers (CRC) develop from adenomas. Knowledge of the
natural history of colorectal adenomas, which is not directly observable for ethical reasons …

Identification of the serrated neoplasia pathway has improved our understanding of the
pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the …