Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

Scientific evidence based on neuroimaging approaches over the last decade has
demonstrated the efficacy of physical activity improving cognitive health across the human …

Innate immunity within the central nervous system (CNS) is primarily provided by resident
microglia. Microglia are pivotal in immune surveillance and also facilitate the co‐ordinated …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and age-
related macular degeneration (AMD), share two characteristics in common:(1) a disease …

New neurons are produced each day in the hippocampus through the process of
neurogenesis. Both mental and physical training can modify this process by increasing the …

Background Aging is associated with low-grade neuroinflammation that includes basal
increases in proinflammatory cytokines and expression of inflammatory markers on …

The increasing burden of major depressive disorder makes the search for an extended
understanding of etiology, and for the development of additional treatments highly …

The hippocampus is critical for several aspects of learning and memory and is unique
among other cortical regions in structure, function and the potential for plasticity. This …

Alzheimer disease (AD) is a progressive, neurodegenerative disease characterised in life by
cognitive decline and behavioural symptoms and post-mortem by the neuropathological …

Peripheral stimulation of the innate immune system with LPS causes exaggerated
neuroinflammation and prolonged sickness behavior in aged mice. Regular moderate …