Nogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting
axonal regeneration after central nervous system (CNS) injury. This review summarizes …

Studies carried out during the last 2 decades have dramatically increased our knowledge of
the pathways and mechanisms of intracellular membrane traffic, most recently due to the …

In mammals, a single pannexin1 gene (Panx1) is widely expressed in the CNS including the
inner and outer retinae, forming large-pore voltage-gated membrane channels, which are …

Gap junction is a cell-cell communication junction type found in virtually all mammalian
epithelia and endothelia and provides the necessary “signals” to coordinate physiological …

Background Many signaling molecules and pathways that regulate gap junctions (GJs)
protein expression and function are, in fact, also controlled by GJs. We, therefore …

Background Information Hepatocytes, which perform the main functions of the liver, are
particularly vulnerable to toxic agents such as cadmium, an environmental pollutant. To …

Plasma membrane-associated channels known as gap junctions, along with their protein
building blocks—connexins—have an important functional role in a range of immunological …

The C-terminus (CT) of rCx46 consists of 186 residues (H230-I416). Recent studies showed
that rCx46 28.2, truncated after H243, altered the formation of functional hemichannels when …

The human skin is a complex organ that provides a protective barrier against fluid loss from
within, and against assault from the external environment by chemicals (irritants), physical …

The connexins are a family of 21 proteins that represent the structural units of intercellular
gap junctions and single membrane hemichannels. These channels provide a means for …