Anti-PD-L1 antibodies and uses therefor

GJ Freeman, R Ahmed, TD Jones, FJ Carr… - US Patent …, 2013 - Google Patents
JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z, 12Z-octadecadienoyl)-sn-
glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC (= O) OC [C …

Bispecific antibodies and trispecific immunocytokines for targeting the immune system against cancer: preparing for the future

P Fournier, V Schirrmacher - BioDrugs, 2013 - Springer
Monoclonal anti-tumor antibodies (mAbs) that are clinically effective usually recruit, via their
constant fragment (Fc) domain, Fc receptor (FcR)-positive accessory cells of the immune …

Optically induced cell fusion using bispecific nanoparticles

D Yeheskely‐Hayon, L Minai, L Golan, EJ Dann… - Small, 2013 - Wiley Online Library
Redirecting the immune system to eliminate tumor cells is a promising alternative to
traditional cancer therapies, most often requiring direct interaction between an immune …

The Development of Bispecific Hexavalent Antibodies as a Novel Class of DOCK-AND-LOCKTM (DNLTM) Complexes

CH Chang, EA Rossi, Y Wang, TM Cardillo… - Antibodies, 2013 - mdpi.com
The DOCK-AND-LOCKTM (DNLTM) method provides a modular approach to develop
multivalent, multifunctional complexes of defined structures, of which bispecific hexavalent …

Therameutin modulators

GM Housey - US Patent 8,367,038, 2013 - Google Patents
This invention relates to agents that are inhibitors or activa tors of variant forms of
endogenous proteins and novel meth ods of identifying Such variants. Of particular interest …

Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators

GM Housey - US Patent 8,431,110, 2013 - Google Patents
DZGOZELMFRSXME-KVSWJAHQSA-N O= C (NC1= CC= CC (C (F)(F) F)= C1) C1= CC=
CC (/C= N/NC2= NC (N3CCOCC3)= C (F) C= N2)= N1 Chemical compound O= C (NC1 …

A Mechanistic Dissection of Polyethylenimine Mediated Transfection of Chinese Hamster Ovary Cells

OL Mozley - 2013 - etheses.whiterose.ac.uk
Biopharmaceutical production through transient gene expression (TGE) is used within
industry for the rapid supply of product for early stage testing. A key requirement of the …

Nonclinical Development of Multi-targeting Biopharmaceuticals

RA Prell, DW Lee, WG Halpern, AV Connor - Nonclinical Development of …, 2013 - Elsevier
Abstracts Advances in antibody engineering technologies have resulted in a number of
novel biopharmaceutical formats capable of binding to multiple targets. This flexibility …

[PDF][PDF] Antibody-Redirected T-Cell Immunotherapy for Brain Tumors

BD Choi - 2013 - dukespace.lib.duke.edu
The most common primary malignant brain tumor, glioblastoma, is uniformly fatal. Current
therapy provides only incremental benefits in survival and is often incapacitating owing to …

Von FLT3 über ENG bis OX40: Optimierung von anti-Tumor-Antikörpern durch verbesserte Rekrutierung immunologischer Effektorzellen

M Hofmann - 2013 - tobias-lib.ub.uni-tuebingen.de
Chimärisierte und humanisierte monoklonale Antikörper der zweiten Generation haben die
Therapie und Prognose einiger malignen Erkrankungen bereits stark verbessert. In vielen …