Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine
Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into
bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs …
bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs …
Therapeutic potential of mesenchymal stem cells in regenerative medicine
DM Patel, J Shah, AS Srivastava - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self‐renew and
also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal …
also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal …
Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells
G Siegel, T Kluba, U Hermanutz-Klein, K Bieback… - BMC medicine, 2013 - Springer
Abstract Background Mesenchymal stromal cells (MSCs) are attractive for cell-based
therapies ranging from regenerative medicine and tissue engineering to immunomodulation …
therapies ranging from regenerative medicine and tissue engineering to immunomodulation …
Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified …
J Bartunek, A Behfar, D Dolatabadi… - Journal of the American …, 2013 - jacc.org
Objectives: This study sought to evaluate the feasibility and safety of autologous bone
marrow–derived and cardiogenically oriented mesenchymal stem cell therapy and to probe …
marrow–derived and cardiogenically oriented mesenchymal stem cell therapy and to probe …
Cardiac stem cell therapy and the promise of heart regeneration
JC Garbern, RT Lee - Cell stem cell, 2013 - cell.com
Stem cell therapy for cardiac disease is an exciting but highly controversial research area.
Strategies such as cell transplantation and reprogramming have demonstrated both …
Strategies such as cell transplantation and reprogramming have demonstrated both …
Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after …
AR Williams, KE Hatzistergos, B Addicott, F McCall… - Circulation, 2013 - Am Heart Assoc
Background—Because mesenchymal stem cells (MSCs) induce proliferation and
differentiation of c-kit+ cardiac stem cells (CSCs) in vivo and in vitro, we hypothesized that …
differentiation of c-kit+ cardiac stem cells (CSCs) in vivo and in vitro, we hypothesized that …
Anti‐donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?
Mesenchymal stem (stromal) cells (MSCs) have potent anti‐inflammatory/
immunosuppressive properties which underlie much of their therapeutic potential. This fact …
immunosuppressive properties which underlie much of their therapeutic potential. This fact …
Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms
JM Duran, CA Makarewich, TE Sharp… - Circulation …, 2013 - Am Heart Assoc
Rationale: Autologous bone marrow–derived or cardiac-derived stem cell therapy for heart
disease has demonstrated safety and efficacy in clinical trials, but functional improvements …
disease has demonstrated safety and efficacy in clinical trials, but functional improvements …
Mesenchymal stem cell therapy for heart disease
M Gnecchi, E Cervio - Mesenchymal stem cell therapy, 2013 - Springer
Mesenchymal stem cells (MSC) are adult stem cells with capacity for self-renewal and multi-
lineage differentiation. Initially described in bone marrow, MSC are also present in other …
lineage differentiation. Initially described in bone marrow, MSC are also present in other …
Exosomes function in pro-and anti-angiogenesis
M Fernandes Ribeiro, H Zhu, RW Millard… - Current …, 2013 - ingentaconnect.com
Exosomes, a group of small vesicles (30-100 nm), originate when the inward budding of the
endosomal membrane forms multivesicular bodies (MVBs). Exosomes are released into the …
endosomal membrane forms multivesicular bodies (MVBs). Exosomes are released into the …