Tenofovir effect on the kidneys of HIV-infected patients: a double-edged sword?

J Tourret, G Deray, C Isnard-Bagnis - Journal of the American …, 2013 - journals.lww.com
Tenofovir disoproxil fumarate (TDF), the first nucleotidic inhibitor of HIV reverse transcription,
became available in 2001. It has been extensively used worldwide and is now the most …

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

P Marcellin, E Gane, M Buti, N Afdhal, W Sievert… - The Lancet, 2013 - thelancet.com
Background Whether long-term suppression of replication of hepatitis B virus (HBV) has any
beneficial effect on regression of advanced liver fibrosis associated with chronic HBV …

Safety of tenofovir during pregnancy for the mother and fetus: a systematic review

L Wang, AP Kourtis, S Ellington… - Clinical Infectious …, 2013 - academic.oup.com
Tenofovir disoproxil fumarate (TDF) safety during pregnancy has important public health
implications. This review summarizes TDF safety during pregnancy, focusing on pregnancy …

[HTML][HTML] Management of chronic hepatitis B in childhood: ESPGHAN clinical practice guidelines: consensus of an expert panel on behalf of the European Society of …

EM Sokal, M Paganelli, S Wirth, P Socha, P Vajro… - Journal of …, 2013 - Elsevier
More than 360 million persons worldwide (6% of the world population) are chronically
infected by the hepatitis B virus (HBV). Although the incidence of HBV infection has …

[HTML][HTML] Hepatitis B surface antigen levels: association with 5-year response to peginterferon alfa-2a in hepatitis B e-antigen-negative patients

P Marcellin, F Bonino, C Yurdaydin… - Hepatology …, 2013 - Springer
Purpose To investigate the durability of response to peginterferon alfa-2a up to 5 years post-
treatment and factors associated with response in hepatitis B e-antigen (HBeAg)-negative …

Reduction of hepatitis B surface antigen and covalently closed circular DNA by nucleos (t) ide analogues of different potency

DKH Wong, WK Seto, J Fung, P Ip, FY Huang… - Clinical …, 2013 - Elsevier
Background & Aims Few studies have investigated the effects of different nucleos (t) ide
analogues against hepatitis B virus (HBV) on levels of covalently closed circular DNA …

Randomised study comparing 48 and 96 weeks peginterferon α-2a therapy in genotype D HBeAg-negative chronic hepatitis B

P Lampertico, M Viganò, GG Di Costanzo, E Sagnelli… - Gut, 2013 - gut.bmj.com
Objective Treatment with peginterferon α-2a (PegIFN) for 48 weeks is the standard of care
for selected HBeAg-negative patients chronically infected with hepatitis B virus (HBV), but …

[PDF][PDF] Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral load

SC Gordon, Z Krastev, A Horban, J Petersen… - …, 2013 - Wiley Online Library
We evaluated the antiviral response of patients with chronic hepatitis B (CHB) who had
baseline high viral load (HVL), defined as having hepatitis B virus (HBV) DNA≥ 9 log10 …

[HTML][HTML] Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection

MK Celen, D Mert, M Ay, T Dal, S Kaya… - World journal of …, 2013 - ncbi.nlm.nih.gov
AIM: To evaluate the effects of tenofovir disoproxil fumarate (TDF) use during late pregnancy
to reduce hepatitis B virus (HBV) transmission in highly viremic mothers. METHODS: This …

[HTML][HTML] The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes

JE Tavis, X Cheng, Y Hu, M Totten, F Cao… - PLoS …, 2013 - journals.plos.org
Nucleos (t) ide analog therapy blocks DNA synthesis by the hepatitis B virus (HBV) reverse
transcriptase and can control the infection, but treatment is life-long and has high costs and …