Systematic Review and Meta-Analysis of In Vitro Synergy of Polymyxins and Carbapenems
Our objective was to examine the evidence of in vitro synergy of polymyxin-carbapenem
combination therapy against Gram-negative bacteria (GNB). A systematic review and meta …
combination therapy against Gram-negative bacteria (GNB). A systematic review and meta …
Combination therapy for carbapenem-resistant Gram-negative bacteria
AP Zavascki, JB Bulitta… - Expert review of anti …, 2013 - Taylor & Francis
The emergence of resistant to carbapenems Gram-negative bacteria (CR GNB) has severely
challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to …
challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to …
Multidrug-resistant gram-negative bacteria infections in solid organ transplantation
D Van Duin, C van Delden - American Journal of Transplantation, 2013 - amjtransplant.org
Enterobacteriaceae; ESBL, extended-spectrum beta-lactamase; EUCAST, European
Committee on Antimicrobial Susceptibility Testing; FDA, Food and Drug Administration; ICU …
Committee on Antimicrobial Susceptibility Testing; FDA, Food and Drug Administration; ICU …
Synergistic Activity of Colistin and Rifampin Combination against Multidrug-Resistant Acinetobacter baumannii in an In Vitro Pharmacokinetic/Pharmacodynamic …
HJ Lee, PJ Bergen, JB Bulitta, B Tsuji… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Combination therapy may be required for multidrug-resistant (MDR) Acinetobacter
baumannii. This study systematically investigated bacterial killing and emergence of colistin …
baumannii. This study systematically investigated bacterial killing and emergence of colistin …
Mutations of the ompK36 Porin Gene and Promoter Impact Responses of Sequence Type 258, KPC-2-Producing Klebsiella pneumoniae Strains to Doripenem and …
Doripenem-colistin exerts synergy against some, but not all, Klebsiella pneumoniae
carbapenemase (KPC)-producing K. pneumoniae strains in vitro. We determined if …
carbapenemase (KPC)-producing K. pneumoniae strains in vitro. We determined if …
PK/PD models in antibacterial development
Highlights•In vitro PK/PD models are less costly and resource-intensive and permit
investigations of considerable duration which may not be feasible in animals.•Mouse thigh …
investigations of considerable duration which may not be feasible in animals.•Mouse thigh …
Visible light mediated killing of multidrug-resistant bacteria using photoacids
Increasing acidity is a promising method for bacterial inactivation by inhibiting the synthesis
of intracellular proteins at low pH. However, conventional ways of pH control are not …
of intracellular proteins at low pH. However, conventional ways of pH control are not …
Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies
Remote loading of azithromycin into liposomes, and subsequent release behavior in the
presence of colistin, has been investigated with a view to understand the potential of …
presence of colistin, has been investigated with a view to understand the potential of …
In vitro activity of doripenem alone and in multi-agent combinations against extensively drug-resistant Acinetobacter baumannii and Klebsiella pneumoniae
SA Clock, S Tabibi, L Alba, CJ Kubin, S Whittier… - … and Infectious Disease, 2013 - Elsevier
Carbapenems are increasingly needed to treat infections caused by drug-resistant gram-
negative bacilli (GNB), but carbapenem resistance is increasing. We evaluated the activity of …
negative bacilli (GNB), but carbapenem resistance is increasing. We evaluated the activity of …
Multidrug-resistant bacteria in organ transplantation: an emerging threat with limited therapeutic options
G Patel, MM Rana, S Huprikar - Current infectious disease reports, 2013 - Springer
Multidrug-resistant organisms (MDROs) are an emerging threat in solid organ
transplantation (SOT). The changing epidemiology of these MDROs is reviewed along with …
transplantation (SOT). The changing epidemiology of these MDROs is reviewed along with …