Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

The development of the musculoskeletal system is a complex process that involves very
precise control of bone formation and growth as well as remodeling during postnatal life …

The field of hemichannels is closely related to the purinergic signaling and both areas have
been growing in parallel. Hemichannels open in response to a wide range of stressful …

Connexin43 (Cx43) is the most abundant gap junction protein expressed in bone cells and
plays a central role in cell-to-cell communication in the skeleton. Findings of the last decade …

Osteoarthritis (OA) is a debilitating chronic condition widely prevalent in ageing populations.
Because the pathology of the disease includes cartilage erosion and joint remodelling, OA …

Cell–cell and cell–matrix interactions are essential for cell differentiation, function, and
maintenance of skeletal tissue. Gap junction proteins, composed of connexin (Cx) and …

2011~ 2012 年期间, 骨相关细胞生物学, 骨矿化, 骨骼系统整体调节, 骨骼系统与其他系统相互
作用等领域得到广泛深入研究——成骨细胞分化过程中β-连环蛋白(catenin) 共转录因子Lefl …

Innate immunity is the first line of defense against pathogen-associated molecular patterns
(PAMPs) and endogenous danger-associated molecular patterns (DAMPs) in the central …

Fibronectin (FN) containing a heparin-binding domain (HBD) and an Arg-Gly-Asp (RGD)
domain can promote cell adhesion and proliferation compared to FN that contained only …