The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

The use of alternatives to allogeneic blood continues to rest on the principles that blood
transfusions have inherent risks, associated costs, and affect the blood inventory available …

Background Each year, worldwide, about 3 million people die as a result of trauma, many
after reaching hospital. Among trauma patients who do survive to reach hospital, bleeding is …

Thrombosis has long been recognized as a potentially lifethreatening complication in
children with congenital heart disease (CHD), children with acquired heart disease, and in …

Background: Approximately one-third of patients undergoing total knee replacement require
one to three units of blood postoperatively. Tranexamic acid (TXA) is a synthetic …

The objective of this study was to determine if tranexamic acid (TXA) applied topically
reduced postoperative bleeding and transfusion rates after primary total hip arthroplasty …

The CRASH-2 trial results have prompted trauma centers to contemplate whether
tranexamic acid (TXA) should be added to their armamentarium for the treatment of bleeding …

Background The use of antifibrinolytic medications in hip and knee arthroplasty reduces
intraoperative blood loss and decreases transfusion rates postoperatively. Tranexamic acid …

Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when
bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury …

Background To evaluate the effectiveness and safety of tranexamic acid (TEA) treatment in
reducing perioperative blood loss and transfusion for patients receiving primary unilateral …