The role of Propionibacterium acnes in acne and in a wide range of inflammatory diseases
is well established. However, P. acnes is also responsible for infections involving implants …

The generation of wear debris is an inevitable result of normal usage of joint replacements.
Wear debris particles stimulate local and systemic biological reactions resulting in chronic …

These guidelines are intended for use by infectious disease specialists, orthopedists, and
other healthcare professionals who care for patients with prosthetic joint infection (PJI). They …

Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

Background It has been hypothesized that bacterial biofilms on breast implants may cause
chronic inflammation leading to capsular contracture. The association between bacterial …

We previously showed that culture of samples obtained by prosthesis vortexing and
sonication was more sensitive than tissue culture for prosthetic joint infection (PJI) diagnosis …

Swab Cultures Are Not As Effective As Tissue Cultures for Di... : Clinical Orthopaedics and
Related Research® Swab Cultures Are Not As Effective As Tissue Cultures for Diagnosis of …

The failure of antibiotic therapies to clear Pseudomonas aeruginosa lung infection, the key
mortality factor for cystic fibrosis (CF) patients, is partly attributed to the high tolerance of P …

Background Periprosthetic infection about the knee is a devastating complication that may
affect between 1% and 5% of knee replacement. With over 79 000 knee replacements being …

Aseptic loosening of total joint replacements is driven by the reaction of macrophages to
foreign body particles released from the implant. It was hypothesized that the macrophages' …