The incidence of obesity and insulin resistance is growing, and the increase in type 2
diabetes mel-litus (DM2) constitutes one of the biggest challenges for our healthcare …

Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas …

Background. Age-related muscle weakness due to atrophy and fatty infiltration in orofacial
muscles may be related to swallowing deficits in older adults. An important component of …

Objective: The goal of enhanced nutrition in critically ill patients is to improve outcome by
reducing lean tissue wasting. However, such effect has not been proven. This study aimed to …

Abstract Background and Aims The pathogenesis of non‐alcoholic fatty liver disease
(NAFLD) is now focusing on its organ cross‐talk with not only adipose tissue but also …

Aims/hypothesis: While lipid deposition in the skeletal muscle is considered to be involved in
obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per …

Abstract The 3T3-L1 cell line, derived from 3T3 cells, is widely used in biological research
on adipose tissue. 3T3-L1 cells have a fibroblast-like morphology, but, under appropriate …

Cellular cholesterol levels are controlled by endoplasmic reticulum (ER) sterol sensing
proteins, which include Scap and Insig-1. With cholesterol sufficiency, Insig inhibits the …

Context: The accumulation of intramyocellular lipids (IMCLs) and mitochondrial dysfunction
in skeletal muscle have been associated with insulin resistance in obesity. Endurance …

Lower skeletal muscle mitochondrial oxidative phosphorylation capacity (OXPHOS) and
intramyocellular lipid (IMCL) accumulation have been implicated in the etiology of insulin …