Over the past years, knowledge and evidence about the existence of crosstalks between
cellular organelles and their potential effects on survival or cell death have been constantly …

Mitochondria contain mtDNA derived from the ancestral endosymbiont genome. Important
subunits of the oxidative phosphorylation system, which supplies cells with the energy …

Human mitochondrial transcription factor A (TFAM) is a high-mobility group (HMG) protein at
the nexus of mitochondrial DNA (mtDNA) replication, transcription, and inheritance. Little is …

Lon protease is a multifunction protein and operates in protein quality control and stress
response pathways in mitochondria. Human Lon is upregulated under oxidative and hypoxic …

Mitochondrial proteostasis depends on a hierarchical system of tightly controlled quality
surveillance mechanisms. Proteases within mitochondria take center stage in this network …

Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell
division in response to stress and also degrades misfolded and damaged proteins. Subunits …

Loss of skeletal muscle is a serious consequence of cancer as it leads to weakness and
increased risk of death. To better understand the interplay between urothelial carcinoma and …

Mitochondrial maintenance crucially depends on the quality control of proteins by various
chaperones, proteases and repair enzymes. While most of the involved components have …

Peroxisomes are remarkably dynamic organelles that participate in a diverse array of
cellular processes, including the metabolism of lipids and reactive oxygen species. In order …

The human mitochondrial ATP-dependent Lon protease functions in regulating the
metabolism and quality control of proteins and mitochondrial DNA (mtDNA). However, the …