A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs
amantadine and rimantadine, whose use has been discontinued due to widespread drug …

The type A influenza virus matrix protein 2 (M2) is a highly selective proton channel in the
viral envelope. Because of its crucial role in viral infection and replication, the M2 channel …

Anti-influenza drugs, amantadine and rimantadine, targeting the M2 channel from influenza
A virus are no longer effective because of widespread drug resistance. S31N is the …

We have synthesized and characterized a series of compounds containing the 3-
azatetracyclo [5.2. 1.15, 8.01, 5] undecane scaffold designed as analogues of amantadine …

We here report on the synthesis of new series of polycyclic amines initially designed as ring-
rearranged analogs of amantadine and featuring pentacyclo, hexacyclo, and octacyclo …

The influenza virus M2 protein is a well-validated yet underexploited proton-selective ion
channel essential for influenza virus infectivity. Because M2 is a toxic viral ion channel …

Hepatitis C virus (HCV) infects an estimated 170–200 million people worldwide and is
associated with life-threatening liver diseases such as cirrhosis and hepatocellular …

The thesis comprises five chapters. Chapter one, the introduction, starts with a brief
discussion of the more famous Pd catalysed reactions and their relevance to Pd as a catalyst …

Ces travaux de thèse s' inscrivent dans un projet à long terme concernant le développement
de nouvelles réactions de contraction de cycle originales afin d'accéder à des édifices …