RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …

Self‐assembled DNA nanostructures have emerged as a type of nano‐biomaterials with
precise structures, versatile functions and numerous applications. One particularly promising …

Nanotechnology has allowed the construction of various nanostructures for applications,
including biomedicine. However, a simple target-specific, economical, and biocompatible …

DNA is a versatile scaffold for molecular sensing in living cells, and various cellular
applications of DNA nanodevices have been demonstrated. However, the simultaneous use …

Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and
hexanediol are shown to significantly increase nuclease resistance under serum conditions …

Due to structural flexibility, RNase sensitivity, and serum instability, RNA nanoparticles with
concrete shapes for in vivo application remain challenging to construct. Here we report the …

Nanocarriers are a new type of nonviral gene carriers, many of which have demonstrated a
broad range of pharmacological and biological properties, such as being biodegradable in …

DNA is emerging as a powerful substrate for nanoconstruction.[1] Three dimensional (3D)
polyhedra based on DNA have potential as “smart” delivery devices for molecular cargo in …

Single-stranded oligonucleotides are important as research tools, as diagnostic probes, in
gene therapy and in DNA nanotechnology. Oligonucleotides are typically produced via solid …

In addition to its fundamental function as a genetic code carrier, the utilization of DNA in
various material applications has been actively explored over the past several decades …