Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral
activation and effort-related processes. Although nucleus accumbens (NAc) DA depletions …

Over the last few years, the concept of food addiction has become a common feature in the
scientific literature, as well as the popular press. Nevertheless, the use of the term addiction …

Background Motivational impairments are a core feature of schizophrenia and although
there are numerous reports studying this feature using clinical rating scales, objective …

Subjects routinely control the vigor with which they emit motoric responses. However, the
bulk of formal treatments of decision-making ignores this dimension of choice. A recent …

Motivated behaviors are often characterized by a high degree of behavioral activation, and
work output and organisms frequently make effort-related decisions based upon cost/benefit …

The present review article summarizes and expands upon the discussions that were initiated
during a meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition …

The lack of initiative, drive or effort in patients with schizophrenia is linked to marked
functional impairments. However, our assessment of effort and motivation is crude, relying …

Abstract Rationale Selective 5-HT 2C receptor agonists, such as lorcaserin, are being
developed for the treatment of obesity. Studies suggest that they may also have therapeutic …

Rationale Mathematical models can assist the interpretation of the effects of interventions on
schedule-controlled behaviour and help to differentiate between processes that may be …

Functional relations between an animal's environment and its behavior are established,
maintained, altered, and elaborated by experience because it has a nervous system …