Novel approaches to minimize ventilator-induced lung injury

E Fan, J Villar, AS Slutsky - BMC medicine, 2013 - Springer
Despite over 40 years of research, there is no specific lung-directed therapy for the acute
respiratory distress syndrome (ARDS). Although much has evolved in our understanding of …

Clinical review: Lung imaging in acute respiratory distress syndrome patients-an update

D Chiumello, S Froio, B Bouhemad, L Camporota… - Critical care, 2013 - Springer
Over the past 30 years lung imaging has greatly contributed to the current understanding of
the pathophysiology and the management of acute respiratory distress syndrome (ARDS). In …

Topographic distribution of tidal ventilation in acute respiratory distress syndrome: effects of positive end-expiratory pressure and pressure support

T Mauri, G Bellani, A Confalonieri… - Critical care …, 2013 - journals.lww.com
Objective: Acute respiratory distress syndrome is characterized by collapse of gravitationally
dependent lung regions that usually diverts tidal ventilation toward nondependent regions …

Accuracy of plateau pressure and stress index to identify injurious ventilation in patients with acute respiratory distress syndrome

PP Terragni, C Filippini, AS Slutsky, A Birocco… - …, 2013 - pubs.asahq.org
Background: Guidelines suggest a plateau pressure (P plat) of 30 cm H2O or less for
patients with acute respiratory distress syndrome, but ventilation may still be injurious …

Effect of different seated positions on lung volume and oxygenation in acute respiratory distress syndrome

J Dellamonica, N Lerolle, C Sargentini, S Hubert… - Intensive care …, 2013 - Springer
Rationale Lung volume available for ventilation is markedly decreased during acute
respiratory distress syndrome. Body positioning may contribute to increase lung volume and …

Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs

M Cereda, K Emami, Y Xin, S Kadlecek… - Critical care …, 2013 - journals.lww.com
Objective: Atelectasis and surfactant depletion may contribute to greater distension—and
thereby injury—of aerated lung regions; recruitment of atelectatic lung may protect these …

Effects of ventilation strategy on distribution of lung inflammatory cell activity

N de Prost, EL Costa, T Wellman, G Musch, MR Tucci… - Critical Care, 2013 - Springer
Introduction Leukocyte infiltration is central to the development of acute lung injury, but it is
not known how mechanical ventilation strategy alters the distribution or activation of …

Micro-Autoradiographic Assessment of Cell Types Contributing to 2-Deoxy-2-[18F]Fluoro-d-Glucose Uptake During Ventilator-Induced and Endotoxemic Lung Injury

D Saha, K Takahashi, N de Prost, T Winkler… - Molecular imaging and …, 2013 - Springer
Purpose The aim of the study was to use micro-autoradiography to investigate the lung cell
types responsible for 2-deoxy-2-[18 F] fluoro-d-glucose (FDG) uptake in murine models of …

Extracorporeal membrane oxygenation in adults with acute respiratory distress syndrome

E Hirshberg, RR Miller III, AH Morris - Current opinion in critical …, 2013 - journals.lww.com
Extracorporeal membrane oxygenation in adults with acute res... : Current Opinion in Critical
Care Extracorporeal membrane oxygenation in adults with acute respiratory distress syndrome …

Alveolar recruitment during mechanical ventilation–Where are we in 2013?

G Tusman, SH Bohm, F Suarez-Sipmann - Trends in Anaesthesia and …, 2013 - Elsevier
Lung recruitment maneuvers have gained popularity over the last years. Their main goal is
to overcome lung collapse in order to improve lung function and to decrease the chance of …