Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

It is well known that the RAS (renin–angiotensin system) plays a key role in the modulation
of many functions in the body. AngII (angiotensin II) acting on AT1R (type 1 AngII receptor) …

The renin–angiotensin system (RAS) has recently been extended by the addition of a novel
axis consisting of the angiotensin-converting enzyme 2 (ACE2), the heptapeptide …

The renin–angiotensin system (RAS) plays a key pathogenic role in heart failure. The
adverse effects of angiotensin II (Ang II), a major player of the RAS, contributes to the …

Angiotensin II (AngII), a peptide hormone released by adipocytes, can be catabolized by
adipose angiotensin-converting enzyme 2 (ACE2) to form Ang (1–7). Co-expression of AngII …

Transforming growth factor-β (TGF-β) is pivotal in diabetic nephropathy (DN). Angiotensin
converting enzyme-2 (ACE2) converts angiotensin II (Ang II) to angiotensin 1–7 (Ang–(1–7)) …

The activation of the classical angiotensin (Ang)‑converting enzyme (ACE)/Ang II/Ang II type
1 receptor (AT1R) axis of the renin‑angiotensin system (RAS) has been associated with islet …

CGEN-856S is a novel Mas agonist. Herein, we examined the effects of this peptide on
isoproterenol (ISO)-induced cardiac remodeling and myocardial infarction (MI) injury. We …

The counter-regulatory axis of the renin–angiotensin system (RAS) is a novel therapeutic
target in cardiovascular disease. Pathophysiological effects mediated via angiotensin II (Ang …

Glycogen synthase (GS) is activated by glucose/glycogen depletion in skeletal muscle cells,
but the contributing signaling pathways, including the chief GS regulator GSK3, have not …