Human survival has relied upon the ability to withstand starvation through energy storage,
the capacity to fight off infection by a proinflammatory immune response, and the ability to …

Satellite cells can be isolated from skeletal muscle biopsies, activated to proliferating
myoblasts and differentiated into multinuclear myotubes in culture. These cell cultures …

Purpose Swimming exercise leads to a nonpathological, physiological left ventricular
hypertrophy. However, the potential molecular mechanisms are unknown. We investigated …

Obesity in humans is often associated with metabolic inflexibility, but the underlying
molecular mechanisms remain incompletely understood. The aim of the present study was …

The purpose of this study was to determine if site-specific phosphorylation at the level of Akt
substrate of 160 kDa (AS160) is altered in skeletal muscle from sedentary humans across a …

METHODS: Here, lean, obese and T2D subjects underwent a euglycemic-hyperinsulinemic
clamp, and vastus lateralis muscle biopsies were obtained before, and at 30 and 180 min …

Within 2–3 days of starvation, pronounced insulin resistance develops, possibly mediated by
increased lipid load. Here, we show that one exercise bout increases mitochondrial fatty …

Resistance to insulin actions is contributing to many metabolic disturbances. Such factors as
age, sex, nutrition, body fat, and physical activity determine body insulin resistance. Present …

The aims of the work described in this thesis are to examine the impact of physical
activity/exercise and energy balance on metabolic control and inflammation and specifically …

This thesis was an investigation of laforin, malin, and AMPK and the possible relationships
these proteins share with glycogen content. Rats underwent a 24 h fast followed by a 24 h re …