Heart failure with preserved ejection fraction (HFpEF) is a growing public health problem
that accounts for approximately half of all prevalent heart failure (HF). 1, 2 Once believed to …

LeWinter and Granzier Titin and Human Disease 939 thick filament), but the expression ratio
of compliant (N2BA) to stiff (N2B) titin is variable (in human control left ventricular …

Objective: To identify causative genes for centronuclear myopathies (CNM), a
heterogeneous group of rare inherited muscle disorders that often present in infancy or early …

Aims In diabetes mellitus, heart failure with preserved ejection fraction (HFPEF) is a
significant comorbidity. No therapy is available that improves cardiovascular outcomes. The …

Striated respiratory muscles are necessary for lung ventilation and to maintain the patency of
the upper airway. The basic structural and functional properties of respiratory muscles are …

Mechanical forces provide fundamental physiological stimulus in living organisms. Recent
investigations demonstrated how various types of mechanical load, like strain, pressure …

Reactive oxygen–nitrogen species play important roles in physiological and pathological
processes in the heart. This review will focus on the activation of matrix metalloproteinases …

Objective: To investigate whether sarcomeric dysfunction contributes to muscle weakness in
facioscapulohumeral muscular dystrophy (FSHD). Methods: Sarcomeric function was …

Our recent study indicated that RNA binding motif 20 (Rbm20) alters splicing of titin and
other genes. The current goals were to understand how the Rbm20-/-rat is related to …

Titin plays crucial roles in sarcomere organization and cardiac elasticity by acting as an
intrasarcomeric molecular spring. A mutation in the tenth Ig-like domain of titin's spring …