The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

A glomerulus is the network of capillaries that resides in the Bowman's capsule that
functions as a filtration unit of kidney. The glomerular function ensures that essential plasma …

The noncanonical Wnt/planar cell polarity (PCP) pathway controls a variety of cell behaviors
such as polarized protrusive cell activity, directional cell movement, and oriented cell …

Dogs of the soft-coated wheaten terrier breed (SCWT) are predisposed to adult-onset,
genetically complex, protein-losing nephropathy (average onset age= 6.3±2.0 years). A …

Glomerular filtration has always attracted the interest of nephrologists and renal researchers
alike. Although several key questions on the structure and function of the kidney filter may …

Somatic cell fusion is an essential component of skeletal muscle development and growth
and repair from injury. Additional cell types such as trophoblasts and osteoclasts also …

Klíčová slova: nefrotický syndrom, FSGS, MCD, podocin, NPHS2, polymorfismy VEGF
Nefrotický syndrom (NS), způsobený nemocí minimálních změn glomerulů (MCD) nebo …

Focal segmental glomerulosclerosis (FSGS) is the most common cause of therapy-resistant
nephrotic syndrome in children worldwide. Transient Receptor Potential Cation Channel …

MCNS is the most common cause of significant morbidity amongst the childhood
glomerulonephritides. However, its pathogenesis is still unknown. Studies attempting to …

The formation of the primary urine occurs at the filtration barrier, composed of fenestrated
endothelia, glomerular basement membrane and the podocyte foot processes. A molecular …