The tumor microenvironment includes cells such as fibroblasts, immune cells, endothelial
cells, as well as extracellular matrix (ECM), proteases, and cytokines. Together, these …

Neoplastic transformation is caused by accumulation of genetic lesions that ultimately
convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited …

Rationale: Cardiomyocytes in adult mammalian hearts are terminally differentiated cells that
have exited from the cell cycle and lost most of their proliferative capacity. Death of mature …

Abstract MicroRNAs (miRNA) precursor (pre-miRNA) molecules can be processed to
release a miRNA/miRNA* duplex. In the canonical model of miRNA biogenesis, one strand …

To study the physiological role of a single microRNA (miRNA), we generated transgenic
mice expressing the miRNA precursor miR-17 and found that the mature miR-17-5p and the …

Background Patients with Type 1 Diabetes (T1D) are particularly vulnerable to development
of Diabetic nephropathy (DN) leading to End Stage Renal Disease. Hence a better …

MicroRNAs are known to play regulatory roles in gene expression associated with cancer
development. We analyzed levels of the microRNA miR-24 in patients with breast carcinoma …

Chemotherapy has been widely used in treating cancer patients. Despite the tremendous
progress in cancer treatment achieved during the last decades, drug resistance still …

MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that are made up of
18–25 nucleotides that function in post-transcriptional gene regulation. The expression of …

This study was designed to explore the role of versican in the development of hepatocellular
carcinoma (HCC). Ectopic expression of the versican 3′‐untranslated region (3′‐UTR) …