Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of
elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria …

Importance Mutations in the progranulin gene are known to cause diverse clinical
syndromes, all attributed to frontotemporal lobar degeneration. We describe 2 patients with …

Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is
implicated in neuronal survival on the basis that mutations in the GRN gene causing …

Genetic variants in the granulin (GRN) gene have been shown to increase the risk of
Alzheimer's disease (AD). Here, we report that the A allele of rs5848 in GRN reduces …

Background and purpose Common genetic variants (rs5848 and rs646776) have been
reported as regulators of blood progranulin (GRN) levels in healthy individuals. Methods To …

Mutations in progranulin gene (GRN) are the most common cause of autosomal dominant
familial frontotemporal lobar degeneration (FTLD). In addition, GRN variability influences the …

Plasma progranulin (PGRN) levels constitute a potentially invaluable biomarker for
neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and …

The recognition of people and/or populations at a high risk for the development of various
types of neurological disorders and diseases is not only key to improved screening …

Recent studies strongly suggest a significant association between diabetes mellitus and
Alzheimer Disease (AD) justifying the term “type 3 diabetes”. Studies show that impairment …

Durch Messung der Progranulinspiegel im Blutplasma mittels ELISA konnte in vorliegender
Arbeit ein signifikanter Unterschied zwischen bipolaren Patienten und Kontrollen …