Modeling the blood–brain barrier using stem cell sources

ES Lippmann, A Al-Ahmad, SP Palecek… - Fluids and Barriers of the …, 2013 - Springer
The blood–brain barrier (BBB) is a selective endothelial interface that controls trafficking
between the bloodstream and brain interstitial space. During development, the BBB arises …

In Vitro and in Vivo Evaluation of Lactoferrin-Conjugated Liposomes as a Novel Carrier to Improve the Brain Delivery

FYJ Huang, WJ Chen, WY Lee, ST Lo, TW Lee… - International journal of …, 2013 - mdpi.com
In this study, lactoferrin-conjugated PEGylated liposomes (PL), a potential drug carrier for
brain delivery, was loaded with radioisotope complex, 99mTc labeled N, N-bis (2 …

[HTML][HTML] Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin

W Du, D Gerald, CA Perruzzi… - Laboratory …, 2013 - Elsevier
Vascular tumors are endothelial cell neoplasms whose cellular and molecular mechanisms,
leading to tumor formation, are poorly understood, and current therapies have limited …

Computational modeling of angiogenesis: towards a multi-scale understanding of cell–cell and cell–matrix interactions

SEM Boas, MM Palm, P Koolwijk… - Mechanical and chemical …, 2013 - Springer
Combined with in vitro and in vivo experiments, mathematical and computational modeling
are key to unraveling how mechanical and chemical signaling by endothelial cells …

Decorin potentiates interferon-γ activity in a model of allergic inflammation

C Bocian, AK Urbanowitz, RT Owens, RV Iozzo… - Journal of Biological …, 2013 - ASBMB
The proteoglycan decorin modulates leukocyte recruitment during delayed-type
hypersensitivity responses. Decorin-deficient (Dcn−/−) mice show reduced edema formation …

Secreted luciferase for in vivo evaluation of systemic protein delivery in mice

SS El-Amouri, P Cao, C Miao, D Pan - Molecular biotechnology, 2013 - Springer
A naturally secreted Gaussia luciferase (Gluc) has been utilized as a reporter for
bioluminescence imaging (BLI) evaluation. However, the potential application of Gluc for in …

Stretch in brain microvascular endothelial cells (cEND) as an in vitro traumatic brain injury model of the blood brain barrier

E Salvador, W Neuhaus, C Foerster - JoVE (Journal of Visualized …, 2013 - jove.com
Due to the high mortality incident brought about by traumatic brain injury (TBI), methods that
would enable one to better understand the underlying mechanisms involved in it are useful …

Cooling treatment transiently increases the permeability of brain capillary endothelial cells through translocation of claudin-5

A Inamura, Y Adachi, T Inoue, Y He, N Tokuda… - Neurochemical …, 2013 - Springer
The blood–brain-barrier (BBB) is formed by different cell types, of which brain microvascular
endothelial cells are major structural constituents. The goal of this study was to examine the …

[PDF][PDF] Stretch in Brain Microvascular Endothelial Cells (cEND) as an

E Salvador, W Neuhaus, C Foerster - 2013 - pdfs.semanticscholar.org
Due to the high mortality incident brought about by traumatic brain injury (TBI), methods that
would enable one to better understand the underlying mechanisms involved in it are useful …