[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
UM Zanger, M Schwab - Pharmacology & therapeutics, 2013 - Elsevier
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Developmental expression of drug metabolizing enzymes: impact on disposition in neonates and young children
RN Hines - International journal of pharmaceutics, 2013 - Elsevier
Profound changes in drug metabolizing enzyme expression occurs during development that
impacts drug efficacy and the risk of adverse events in the neonate and young child. A …
impacts drug efficacy and the risk of adverse events in the neonate and young child. A …
RNA-sequencing quantification of hepatic ontogeny of phase-I enzymes in mice
L Peng, JY Cui, B Yoo, SS Gunewardena, H Lu… - Drug Metabolism and …, 2013 - ASPET
Phase-I drug metabolizing enzymes catalyze reactions of hydrolysis, reduction, and
oxidation of drugs and play a critical role in drug metabolism. However, the functions of most …
oxidation of drugs and play a critical role in drug metabolism. However, the functions of most …
Drug metabolizing enzymes in the perinatal and neonatal period: differences in the expression and activity
L Cuzzolin - Current Drug Metabolism, 2013 - ingentaconnect.com
Physiological changes occurring perinatally and in the first month of life can affect the
answer to a pharmacological treatment and the individual response to a drug in terms of …
answer to a pharmacological treatment and the individual response to a drug in terms of …