Living organisms and individual cells continuously adapt to changes in their environment.
Those changes are particularly sensitive to fluctuations in the availability of energy …

Concerns about the increasing rates of obesity in developing countries have led many policy
makers to question the impacts of maternal and early child nutrition on risk of later obesity …

Epigenetic processes are primary candidates when searching for mechanisms that can
stably modulate gene expression and metabolic pathways according to early life conditions …

Several types of epigenetic marks facilitate the complex patterning required for normal
human development. These epigenetic marks include DNA methylation at CpG …

Adverse environments during the fetal and neonatal development period may permanently
program physiology and metabolism, and lead to increased risk of diseases in later life …

Although assisted reproductive technology (ART) has become a routine practice for human
infertility treatment, the etiology of the increased risks for perinatal problems in ART …

The epidemic increase of type 2 diabetes and obesity in developed countries cannot be
explained by overnutrition, physical inactivity and/or genetic factors alone. Epidemiologic …

Obesity is a leading risk factor for impaired glucose tolerance and type 2 diabetes (T2D).
Although the cause of the obesity epidemic is multi-factorial and not entirely clear, the recent …

As natural experiments, famines provide a unique opportunity to test the health
consequences of nutritional deprivation during the critical period of early life. Using data on …

We are in the midst of unparalleled epidemics of obesity and type 2 diabetes—complex
phenotypes originating at the intersection of genetic and environmental risk. As detailed in …