Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Diabetic vascular
complications such as DN can progress despite subsequent glycemic control, suggesting a …

Cell-lineage–specific transcripts are essential for differentiated tissue function, implicated in
hereditary organ failure, and mediate acquired chronic diseases. However, experimental …

A strong case for the deregulation of epigenetic chromatin modifications in the development
and progression of various chronic complications of diabetes has emerged from recent …

Background One in eleven people is affected by chronic kidney disease, a condition
characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological …

CKD progresses with fibrosis and erythropoietin (Epo)-dependent anemia, leading to
increased cardiovascular complications, but the mechanisms linking Epo-dependent …

Background Podocyte injury is an early feature of diabetic nephropathy (DN). Recently,
urinary exosomal Wilm's tumor-1 protein (WT1), shed by renal epithelial cells, has been …

Lipoxins, which are endogenously produced lipid mediators, promote the resolution of
inflammation, and may inhibit fibrosis, suggesting a possible role in modulating renal …

ADAM17 and its inhibitor TIMP3 are involved in nephropathy, but their role in diabetic kidney
disease (DKD) is unclear. Diabetic Timp3−/− mice showed increased albuminuria …

Glomerular hypertrophy is a hallmark of diabetic nephropathy. Akt kinase activated by
transforming growth factor-β1 (TGF-β) plays an important role in glomerular mesangial …

Sex and genetic variation influence the risk of developing diabetic nephropathy and ESRD
in patients with type 1 diabetes. We performed a genome-wide association study in a cohort …