Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …

Medium spiny neurons of the nucleus accumbens serve as the interface between
corticolimbic regions that elicit and modulate motivated behaviors, including those related to …

Accumbal deep brain stimulation (DBS) is a promising therapeutic modality for the treatment
of addiction. Here, we demonstrate that DBS in the nucleus accumbens shell, but not the …

Rationale Deep brain stimulation (DBS) has achieved substantial success as a treatment for
movement disorders such as Parkinson's disease. The therapeutic efficacy and relative lack …

Background Given the problems associated with the escalation in methamphetamine
(METH) use, the identification of more effective treatment strategies is essential. Group II …

Drug addiction is a chronic relapsing disorder for which research has been dedicated to
understand the various factors that contribute to development, loss of control, and …

We previously showed that after repeated exposure to cocaine, D1-like dopamine receptor
(D1DR) stimulation reverses plastic changes of AMPA receptor-mediated signaling in the …

Abstract AMPAR (α-amino-3-hydroxy-5-methylisoxazole-4-propionate glutamate receptor)
stimulation in the nucleus accumbens (NAc) is critical in cocaine seeking. Here, we …

Locomotion and cue-dependent behaviors are modified through corticostriatal signaling
whereby short-term increases in dopamine availability can provoke persistent changes in …

While glutamate in the nucleus accumbens (NAS) contributes to the promotion of drug-
seeking by drug-predictive cues, it also appears to play a role in the inhibition of drug …