Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality
and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function …

Rationale: For many patients with asthma, allergic airway inflammation is primarily a Th2-
weighted process; however, heterogeneity in patterns of inflammation suggests phenotypic …

Purpose Most asthmatic patients have well controlled symptoms with regular treatment, but
some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to …

A significant number of older asthmatics, more often than in previous ages, have poorly
controlled asthma, leading to increased morbidity and mortality. On the other hand, current …

Asthma is one of the most prevalent diseases in the world, for which the mainstay treatment
has been inhaled glucocorticoids (GCs). Despite the widespread use of these drugs …

Background Using microarray profiling of airway epithelial cells, we previously identified a
Th2-high molecular phenotype of asthma based on expression of periostin, CLCA1 and …

Abstract Hypoxia-inducible factor (HIF)-1α is a master regulator of inflammatory activities of
myeloid cells, including neutrophils and macrophages. These studies examine the role of …

Recent genome-wide association studies linked childhood asthma with single-nucleotide
polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome …

Background Systemic glucocorticosteroids are side-effect prone but often necessary for the
treatment of severe asthma (SA). Our goal was to assess the usefulness of medical history …

Objective A well-controlled study in patients with allergic asthma was warranted to assess
dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and …