EAACI position statement on asthma exacerbations and severe asthma
Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality
and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function …
and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function …
Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study
NA Hanania, S Wenzel, K Rosén, HJ Hsieh… - American journal of …, 2013 - atsjournals.org
Rationale: For many patients with asthma, allergic airway inflammation is primarily a Th2-
weighted process; however, heterogeneity in patterns of inflammation suggests phenotypic …
weighted process; however, heterogeneity in patterns of inflammation suggests phenotypic …
Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells
A Vazquez-Tello, R Halwani, Q Hamid… - Journal of clinical …, 2013 - Springer
Purpose Most asthmatic patients have well controlled symptoms with regular treatment, but
some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to …
some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to …
Management of asthma in the elderly patient
AS Melani - Clinical interventions in aging, 2013 - Taylor & Francis
A significant number of older asthmatics, more often than in previous ages, have poorly
controlled asthma, leading to increased morbidity and mortality. On the other hand, current …
controlled asthma, leading to increased morbidity and mortality. On the other hand, current …
Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes
CD Moore, JK Roberts, CR Orton, T Murai… - Drug Metabolism and …, 2013 - ASPET
Asthma is one of the most prevalent diseases in the world, for which the mainstay treatment
has been inhaled glucocorticoids (GCs). Despite the widespread use of these drugs …
has been inhaled glucocorticoids (GCs). Despite the widespread use of these drugs …
[HTML][HTML] A qPCR-based metric of Th2 airway inflammation in asthma
NR Bhakta, OD Solberg, CP Nguyen… - Clinical and translational …, 2013 - Springer
Background Using microarray profiling of airway epithelial cells, we previously identified a
Th2-high molecular phenotype of asthma based on expression of periostin, CLCA1 and …
Th2-high molecular phenotype of asthma based on expression of periostin, CLCA1 and …
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function
LE Crotty Alexander, K Akong-Moore… - Journal of molecular …, 2013 - Springer
Abstract Hypoxia-inducible factor (HIF)-1α is a master regulator of inflammatory activities of
myeloid cells, including neutrophils and macrophages. These studies examine the role of …
myeloid cells, including neutrophils and macrophages. These studies examine the role of …
Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma
V Berce, CEP Kozmus, U Potočnik - The pharmacogenomics journal, 2013 - nature.com
Recent genome-wide association studies linked childhood asthma with single-nucleotide
polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome …
polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome …
[HTML][HTML] Phenotypic predictors of response to oral glucocorticosteroids in severe asthma
M Kupczyk, S Haque, RJM Middelveld, B Dahlén… - Respiratory …, 2013 - Elsevier
Background Systemic glucocorticosteroids are side-effect prone but often necessary for the
treatment of severe asthma (SA). Our goal was to assess the usefulness of medical history …
treatment of severe asthma (SA). Our goal was to assess the usefulness of medical history …
[HTML][HTML] Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma
H Nolte, I Pavord, V Backer, S Spector, T Shekar… - Respiratory …, 2013 - Elsevier
Objective A well-controlled study in patients with allergic asthma was warranted to assess
dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and …
dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and …