EAACI position statement on asthma exacerbations and severe asthma

A Custovic, SL Johnston, I Pavord, M Gaga, L Fabbri… - Allergy, 2013 - Wiley Online Library
Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality
and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function …

Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study

NA Hanania, S Wenzel, K Rosén, HJ Hsieh… - American journal of …, 2013 - atsjournals.org
Rationale: For many patients with asthma, allergic airway inflammation is primarily a Th2-
weighted process; however, heterogeneity in patterns of inflammation suggests phenotypic …

Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells

A Vazquez-Tello, R Halwani, Q Hamid… - Journal of clinical …, 2013 - Springer
Purpose Most asthmatic patients have well controlled symptoms with regular treatment, but
some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to …

Management of asthma in the elderly patient

AS Melani - Clinical interventions in aging, 2013 - Taylor & Francis
A significant number of older asthmatics, more often than in previous ages, have poorly
controlled asthma, leading to increased morbidity and mortality. On the other hand, current …

Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes

CD Moore, JK Roberts, CR Orton, T Murai… - Drug Metabolism and …, 2013 - ASPET
Asthma is one of the most prevalent diseases in the world, for which the mainstay treatment
has been inhaled glucocorticoids (GCs). Despite the widespread use of these drugs …

[HTML][HTML] A qPCR-based metric of Th2 airway inflammation in asthma

NR Bhakta, OD Solberg, CP Nguyen… - Clinical and translational …, 2013 - Springer
Background Using microarray profiling of airway epithelial cells, we previously identified a
Th2-high molecular phenotype of asthma based on expression of periostin, CLCA1 and …

Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function

LE Crotty Alexander, K Akong-Moore… - Journal of molecular …, 2013 - Springer
Abstract Hypoxia-inducible factor (HIF)-1α is a master regulator of inflammatory activities of
myeloid cells, including neutrophils and macrophages. These studies examine the role of …

Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma

V Berce, CEP Kozmus, U Potočnik - The pharmacogenomics journal, 2013 - nature.com
Recent genome-wide association studies linked childhood asthma with single-nucleotide
polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome …

[HTML][HTML] Phenotypic predictors of response to oral glucocorticosteroids in severe asthma

M Kupczyk, S Haque, RJM Middelveld, B Dahlén… - Respiratory …, 2013 - Elsevier
Background Systemic glucocorticosteroids are side-effect prone but often necessary for the
treatment of severe asthma (SA). Our goal was to assess the usefulness of medical history …

[HTML][HTML] Dose-dependent anti-inflammatory effect of inhaled mometasone furoate/formoterol in subjects with asthma

H Nolte, I Pavord, V Backer, S Spector, T Shekar… - Respiratory …, 2013 - Elsevier
Objective A well-controlled study in patients with allergic asthma was warranted to assess
dose-dependency between fractional concentration of exhaled nitric oxide (FeNO) and …