In the twenty-first century, the clinical microbiology laboratory plays a central part in
optimizing the management of infectious diseases and surveying local and global …

Traditional pathogen detection methods in public health infectious disease surveillance rely
upon the identification of agents that are already known to be associated with a particular …

Low-cost DNA sequencing technologies have expanded the role for direct nucleic acid
sequencing in the analysis of genomes, transcriptomes, and the metagenomes of whole …

Next-generation sequencing was used for discovery and de novo assembly of a novel,
highly divergent DNA virus at the interface between the Parvoviridae and Circoviridae. The …

Highlights•Pathogen discovery is critically important to infectious diseases and public
health.•Nearly all new outbreaks are caused by the emergence of novel viruses.•Genomic …

Highlights•Dengue vaccine trial shows limited protection against Dengue 2 but no safety
concerns.•Development of Rift Valley fever vaccines that are safe in pregnant …

During outbreaks of infectious diseases or in cases of severely ill patients, it is imperative to
identify the causative agent. This report describes several events in which virus isolation and …

Globalization and industrialization have dramatically altered the vulnerability of human and
animal populations to emerging and reemerging infectious diseases while shifting both the …

Predicting the emergence of infectious diseases has been touted as one of the most
important goals of biomedical science, with an array of funding schemes and research …

Viruses in the family Bunyaviridae infect a wide range of plant, insect, and animal hosts. Tick-
borne bunyaviruses in the Phlebovirus genus, including Severe Fever with …