The neural circuits of the mammalian neocortex are crucial for perception, complex thought,
cognition, and consciousness. This circuitry is assembled from many different neuronal …

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired
proteasomal function appears to contribute to heart disease. Specific proteasomal …

Spinal muscular atrophy is an inherited motor neuron disease that results from a deficiency
of the survival of motor neuron (SMN) protein. SMN is ubiquitinated and degraded through …

After cell fate specification, differentiating cells must amplify the specific subcellular features
required for their specialized function. How cells regulate such subcellular scaling is a …

La via di segnalazione dei recettori di membrana appartenenti alla famiglia Notch è
estremamente conservata dagli Invertebrati ai Vertebrati e regola numerosi eventi quali …

T lymphoblastic lymphoma/leukemia (T-LL) represent malignant disease of T-cell
progenitors. Dysregulation of Notch1 and IL-7R pathways promotes T-LL, however the …