Clinical implications of antibiotic pharmacokinetic principles in the critically ill

AA Udy, JA Roberts, J Lipman - Intensive care medicine, 2013 - Springer
Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Population pharmacokinetics and dosing simulations of amoxicillin/clavulanic acid in critically ill patients

M Carlier, M Noë, JJ De Waele, V Stove… - Journal of …, 2013 - academic.oup.com
Objectives The objective of this study was to investigate the population pharmacokinetics
and pharmacodynamics of amoxicillin and clavulanic acid in critically ill patients. Methods In …

Risk factors for Pseudomonas aeruginosa pneumonia in the early twenty-first century

J Rello, B Borgatta, T Lisboa - Intensive care medicine, 2013 - Springer
Along with Staphylococcus aureus, Pseudomonas aeruginosa (PSA) heads the list of
pathogens associated with Hospital-acquired pneumonia [1–3]. Indeed, even in patients …

Pharmacodynamic profiling of doripenem, imipenem and meropenem against prevalent Gram-negative organisms in the Asia-Pacific region

P Kiratisin, RA Keel, DP Nicolau - International journal of antimicrobial …, 2013 - Elsevier
Carbapenems are increasingly being utilised owing to the escalating prevalence of
antimicrobial-resistant Gram-negative bacteria from community and hospital settings. In this …

Clinical measures for increased creatinine clearances and suboptimal antibiotic dosing

MW Pletz, J Lipman - Intensive Care Medicine, 2013 - Springer
The pharmacokinetic and pharmacodynamic (PK/PD) parameters of major importance for
vancomycin optimisation are not that easy to define (Table 1). The best clinical study …

Pharmacokinetic and pharmacodynamic modeling of antibiotics and bacterial drug resistance

S Mohamed, A Fazlin - 2013 - diva-portal.org
Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug
Resistance diva-portal.org Digitala Vetenskapliga Arkivet Simple search Advanced search …

Coste-efectividad de doripenem o imipenem en la neumonía asociada al respirador

FJ Carrera-Hueso, R Ferriols-Lisart… - PharmacoEconomics …, 2013 - Springer
Objetivo Evaluar la relación coste-efectividad para el tratamiento empírico de la neumonía
asociada a ventilación mecánica (NAVM) con imipenem o doripenem. Métodos Se diseñó …

[引用][C] Optimizing antibiotic pharmacodynamics for clinical practice

KP Connors, JL Kuti, DP Nicolau - Pharmaceut Anal Acta, 2013