Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …

Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Data from 8 breast cancer genome-sequencing projects identified 25 patients with HER2
somatic mutations in cancers lacking HER2 gene amplification. To determine the phenotype …

Background Various human cancers have ALK gene translocations, amplifications, or
oncogenic mutations, such as anaplastic large-cell lymphoma, inflammatory myofibroblastic …

Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly
for hematologic malignancies. To date, however, genomic biomarkers to direct clinical …

Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common
solid tumor in children. To determine the genetic basis for neuroblastoma, we performed …

The recent surge in high-throughput sequencing of cancer genomes has supported an
expanding molecular classification of cancer. These studies have identified putative …