Human T cell aging and the impact of persistent viral infections
Aging is associated with a dysregulation of the immune response, loosely termed
“immunosenescence.” Each part of the immune system is influenced to some extent by the …
“immunosenescence.” Each part of the immune system is influenced to some extent by the …
Priorities for CMV vaccine development
PR Krause, SR Bialek, SB Boppana, PD Griffiths… - Vaccine, 2013 - Elsevier
A multidisciplinary meeting addressed priorities related to development of vaccines against
cytomegalovirus (CMV), the cause of congenital CMV (cCMV) disease and of serious …
cytomegalovirus (CMV), the cause of congenital CMV (cCMV) disease and of serious …
Cytomegalovirus infection is associated with increased mortality in the older population
GM Savva, A Pachnio, B Kaul, K Morgan… - Aging cell, 2013 - Wiley Online Library
Cytomegalovirus (CMV) is a common herpesvirus infection and stimulates the expansion of
very large numbers of CMV‐specific T cells that reduce the CD 4/CD 8 ratio and suppress …
very large numbers of CMV‐specific T cells that reduce the CD 4/CD 8 ratio and suppress …
The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study
J Strindhall, M Skog, J Ernerudh, M Bengner, S Löfgren… - Age, 2013 - Springer
Abstract The Swedish OCTO and NONA immune longitudinal studies were able to identify
and confirm an immune risk profile (IRP) predictive of an increased 2-year mortality in very …
and confirm an immune risk profile (IRP) predictive of an increased 2-year mortality in very …
Lower proportion of naive peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with …
E Derhovanessian, AB Maier, K Hähnel, H Zelba… - Age, 2013 - Springer
The low percentages of naïve T cells commonly observed in elderly people are thought to be
causally associated with mortality, primarily from infectious disease, and are taken as a …
causally associated with mortality, primarily from infectious disease, and are taken as a …
Seroprevalence of cytomegalovirus, Epstein Barr virus and varicella zoster virus among pregnant women in Bradford: a cohort study
L Pembrey, P Raynor, P Griffiths, S Chaytor, J Wright… - PloS one, 2013 - journals.plos.org
Objective To estimate the seroprevalence of cytomegalovirus (CMV), Epstein Barr virus
(EBV) and varicella zoster virus (VZV) among pregnant women in Bradford by ethnic group …
(EBV) and varicella zoster virus (VZV) among pregnant women in Bradford by ethnic group …
Seropositivity and higher immunoglobulin G antibody levels against cytomegalovirus are associated with mortality in the population-based European prospective …
E Gkrania-Klotsas, C Langenberg… - Clinical infectious …, 2013 - academic.oup.com
Background. The relationship between cytomegalovirus (CMV) infection and mortality
among immunocompetent individuals is uncertain. We aimed to examine whether …
among immunocompetent individuals is uncertain. We aimed to examine whether …
The role of the T cell in age-related inflammation
R Macaulay, AN Akbar, SM Henson - Age, 2013 - Springer
Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic
inflammatory state termed inflammaging. The significance of these phenomena is …
inflammatory state termed inflammaging. The significance of these phenomena is …
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses
W Smith, P Tomasec, R Aicheler, A Loewendorf… - Cell host & …, 2013 - cell.com
Death receptors (DRs) of the TNFR superfamily contribute to antiviral immunity by promoting
apoptosis and regulating immune homeostasis during infection, and viral inhibition of DR …
apoptosis and regulating immune homeostasis during infection, and viral inhibition of DR …
Desirability and feasibility of a vaccine against cytomegalovirus
P Griffiths, S Plotkin, E Mocarski, R Pass, M Schleiss… - Vaccine, 2013 - Elsevier
Publication of a report from the Institute of Medicine in 2000 showing that a vaccine against
cytomegalovirus (CMV) would likely be cost saving was very influential and encouraged the …
cytomegalovirus (CMV) would likely be cost saving was very influential and encouraged the …