Abstract The phosphoinositide 3-kinase-AKT-mammalian target of rapamycin (PI3K-AKT-
mTOR) pathway is a frequently hyperactivated pathway in cancer and is important for tumor …

Recent developments in the study of epithelial ovarian cancer have called into question the
traditional views regarding the site of tumor initiation. Histopathologic studies and genomic …

RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS
binding domain of the p110α subunit of PI3-kinse are resistant to the development of RAS …

Using a panel of non–small cell lung cancer (NSCLC) lines, we show here that MAP-ERK
kinase (MEK) and RAF inhibitors are selectively toxic for the KRAS-mutant genotype …

Purpose: Non–small cell lung cancer (NSCLC) includes a spectrum of radiosensitive and
radioresistant tumors. However, little is known about the molecular determinants of cellular …

OBJECTIVE: The aim of this study is to verify the expression of proteins that are controlled by
miR-let7c, 100 and 218 using immunohistochemistry in tissue microarray representative of …

Epithelial-mesenchymal transition (EMT) is an important developmental process hijacked by
cancer cells for their dissemination. Here, we show that Exo70, a component of the exocyst …

AFP and its receptor (AFPR) are early indicators of HBx-driven hepatocarcinogenesis.
Clinical specimens, normal human liver cells L-02 and HCC cell lines were selected for …

Reversing the aberrant biochemical output of oncogenic Ras proteins is one of the great
challenges in cancer therapeutics; however, it is uncertain which Ras effectors are required …

Oncogenic K-Ras proteins, such as K-RasG12D, accumulate in the active, guanosine
triphosphate (GTP)–bound conformation and stimulate signaling through effector kinases …