Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol,
triglycerides, and total cholesterol are heritable, modifiable, risk factors for coronary artery …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin
ligase complexes use a family of F-box proteins as substrate adaptors to mediate the …

If trait-associated variants alter regulatory regions, then they should fall within chromatin
marks in relevant cell types. However, it is unclear which of the many marks are most useful …

Approaches exploiting trait distribution extremes may be used to identify loci associated with
common traits, but it is unknown whether these loci are generalizable to the broader …

Given the anthropometric differences between men and women and previous evidence of
sex-difference in genetic effects, we conducted a genome-wide search for sexually …

Importance Loss-of-function mutations in the melatonin receptor are associated with insulin
resistance and type 2 diabetes. Additionally, in a cross-sectional analysis of persons without …

Aims/hypothesis Although a family history of type 2 diabetes is a strong risk factor for the
disease, the factors mediating this excess risk are poorly understood. In the InterAct case …