The incidence of fungal infections has increased significantly, so contributing to morbidity
and mortality. This is caused by an increase in antimicrobial resistance and the restricted …

Like other microorganisms, free-living Candida albicans is mainly present in a three-
dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form …

Highlights•Light-based anti-infectives work against biofilms and localized
infections.•Ultraviolet C light will kill all pathogens without killing host mammalian …

Understanding the pathogenesis of an infectious disease is critical for developing new
methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to …

Prevention of pathogen colonization of medical implants is a major medical and financial
issue since infection by microorganisms constitutes one of the most serious complications …

Highlights•Fungal infections affect an expanding population of immunosuppressed
patients.•The current arsenal of antifungal drugs is exceedingly limited.•Toxicity problems …

Introduction: Targeting pathogenetic mechanisms, rather than essential processes,
represents a very attractive alternative for the development of new antibiotics. This may be …

Candida albicans is the most common etiologic agent of systemic fungal infections with
unacceptably high mortality rates. The existing arsenal of antifungal drugs is very limited and …

Rhodotorula species are emergent fungal pathogens capable of causing invasive infections,
primarily fungemia. They are particularly problematic in immunosuppressed patients when …

Objectives Systemic candidal infections are a common problem in hospitalized patients due
to central venous catheters fabricated using silicone biomaterial (SB). We therefore …