Larval zebrafish possess several experimental advantages for investigating the molecular
and neural bases of learning and memory. Despite this, neuroscientists have only recently …

In 1868, Friedrich Miescher completed his medical training and joined the physiological
chemistry laboratory of Felix Hoppe-Seyler to study the chemical composition of biological …

We have generated an inducible system to control the timing of transgene expression in
zebrafish and chick. An estrogen receptor variant (ERT2) fused to the GAL4 transcriptional …

Autophagy is responsible for the degradation of cytoplasmic components and organelles
such as mitochondria. The selective degradation of damaged mitochondria by autophagy is …

The ocular motor system consists of three nerves which innervate six muscles to control eye
movements. In humans, defective development of this system leads to eye movement …

The introduction of mechanism‐based targeted therapies to treat human cancers is fruit of
decades of research into the molecular basis of cancer pathogenesis. Despite the growing …

Background: Hedgehog (Hh) signaling is required for embryogenesis and continues to play
key roles postembryonically in many tissues, influencing growth, stem cell proliferation, and …

We have conducted a screen to identify developmentally regulated enhancers that drive
tissue-specific Gal4 expression in zebrafish. We obtained 63 stable transgenic lines with …

Cells of the developing nervous system undergo incredible proliferation, migrate long
distances, and differentiate morphologically into highly specialized structures. The dynamic …

The zebrafish is an important model for the study of development and disease. Its miniature
size, large numbers and optical clarity make it advantageous for high-throughput in vivo …